Insects help scientists create powerful new materials from nanocarbons

Researchers at Japan’s RIKEN Pioneering Research Institute and Center for Sustainable Resource Science have developed an innovative technique called “in-insect synthesis,” which uses insects as living chemical reactors to create and modify complex nanocarbon molecules. Led by Kenichiro Itami, the team focused on tobacco cutworm caterpillars, leveraging their powerful digestive enzymes to perform precise chemical modifications that are difficult or inefficient in traditional laboratory settings. By feeding the caterpillars a nanocarbon molecule known as [6]MCPP, the insects converted it into a fluorescent derivative, [6]MCPP-oxylene, through an oxidation reaction catalyzed by two specific enzymes, CYP X2 and CYP X3. This enzymatic process was confirmed through advanced analytical techniques and genetic analysis, demonstrating a level of chemical precision not achievable by current lab methods. This breakthrough highlights the potential of using biological systems, such as insects, enzymes, and microbes, to manufacture advanced materials with high efficiency and specificity. The discovery that caterpillar enzymes can insert oxygen atoms into carbon–carbon bonds in nanocarbons opens new avenues for producing functional molecules for applications in aerospace, electronics, and battery technology. The research team envisions further optimization of this approach through genetic tools like CRISPR and directed evolution, enabling the programming of insects to synthesize a wide range of valuable compounds, from glowing sensors to pharmaceuticals. This novel strategy represents a paradigm shift in materials science, moving away from traditional chemical synthesis toward bioengineered production platforms.